Anti-Glucotoxicity Effect of Phytoconstituents via Inhibiting MGO-AGEs Formation and Breaking MGO-AGEs

The therapeutic benefits of phytochemicals in the treatment of various illnesses and disorders are well documented. They show significant promise for the discovery and creation of novel medications for treating a variety of human diseases. Numerous phytoconstituents have shown antibiotic, antioxidan...

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Published inInternational journal of molecular sciences Vol. 24; no. 8; p. 7672
Main Authors Yadav, Neera, Palkhede, Jyoti Dnyaneshwar, Kim, Sun-Yeou
Format Journal Article
LanguageEnglish
Published Switzerland MDPI 21.04.2023
MDPI AG
Subjects
AGEs
Diabetes Mellitus
glucotoxicity
Glycation End Products, Advanced - metabolism
Humans
hyperglycemia
Magnesium Oxide
MGO
phytoconstituents
Pyruvaldehyde - metabolism
Review
wound healing
hyperglycemia
phytoconstituents
wound healing
AGEs
glucotoxicity
MGO
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Summary:The therapeutic benefits of phytochemicals in the treatment of various illnesses and disorders are well documented. They show significant promise for the discovery and creation of novel medications for treating a variety of human diseases. Numerous phytoconstituents have shown antibiotic, antioxidant, and wound-healing effects in the conventional system. Traditional medicines based on alkaloids, phenolics, tannins, saponins, terpenes, steroids, flavonoids, glycosides, and phytosterols have been in use for a long time and are crucial as alternative treatments. These phytochemical elements are crucial for scavenging free radicals, capturing reactive carbonyl species, changing protein glycation sites, inactivating carbohydrate hydrolases, fighting pathological conditions, and accelerating the healing of wounds. In this review, 221 research papers have been reviewed. This research sought to provide an update on the types and methods of formation of methylglyoxal-advanced glycation end products (MGO-AGEs) and molecular pathways induced by AGEs during the progression of the chronic complications of diabetes and associated diseases as well as to discuss the role of phytoconstituents in MGO scavenging and AGEs breaking. The development and commercialization of functional foods using these natural compounds can provide potential health benefits.
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ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms24087672