Human herpes virus 6 encephalitis in immunocompetent patient: An unusual neuroradiological presentation

• Published in: Clinical neurology and neurosurgery Vol. 115; no. 10; pp. 2219 - 2222
• Main Authors: De Simone, M, Muccio, C.F, Megna, A.S, Esposito, G
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.10.2013; Elsevier Limited
• Subjects: Abdomen; Acyclovir - therapeutic use; Adult; Antiviral Agents - therapeutic use; Diffusion Magnetic Resonance Imaging; Encephalitis, Viral - cerebrospinal fluid; Encephalitis, Viral - diagnostic imaging; Encephalitis, Viral - virology; Herpes 6 encephalitis; Herpes viruses; Herpesvirus 6, Human; Humans; Hypotheses; Infections; Jaundice - etiology; Magnetic Resonance Imaging; Male; Neurologic Examination; Neurology; Neurosurgery; Pain - etiology; Paresis - etiology; Patients; Perfusion weighted imaging; Polymerase Chain Reaction; Recovery of Function; Roseolovirus Infections - cerebrospinal fluid; Roseolovirus Infections - diagnostic imaging; Roseolovirus Infections - virology; Tomography, X-Ray Computed; Treatment Outcome; Herpes 6 encephalitis; Perfusion weighted imaging
• ISSN: 0303-8467; 1872-6968
• DOI: 10.1016/j.clineuro.2013.06.015

After gadolinium administration no clear enhancement was seen. [...]DSC-MR showed a decreased relative cerebral blood volume (rCBV=0.713) value within the lesions (Fig. 2). [...]they describe this involvement in structures that are neuroanatomically connected to the amygdaloid complex and the hippocampal formation. [...]they suggested that HHV-6 encephalitis may manifest as widespread limbic encephalitis, that preferentially involves network of cortical and subcortical structures, that are interconnected with the hippocampal formation and amygdaloid complex and that the recognition of this neuroanatomic distribution should be of diagnostic value for HHV-6 encephalitis.