Evaluation of the medicinal potentials of the methanol extracts of the leaves and stems of Halleria lucida

• Published in: Bioresource technology Vol. 99; no. 10; pp. 4158 - 4163
• Main Authors: Adedapo, A.A., Jimoh, F.O., Koduru, S., Masika, P.J., Afolayan, A.J.
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.07.2008; [New York, NY]: Elsevier Ltd; Elsevier Science
• Subjects: Antibacterial properties; Antioxidant activities; Antioxidants - analysis; Bacillus cereus; Bacillus cereus - metabolism; Biological and medical sciences; Biological Assay; Biotechnology - methods; Biphenyl Compounds - analysis; Dose-Response Relationship, Drug; Free Radical Scavengers; Fundamental and applied biological sciences. Psychology; General pharmacology; Halleria lucida; Hydrazines - analysis; Medical sciences; Medicinal evaluation; Microbial Sensitivity Tests; Models, Statistical; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Phenol - analysis; Picrates; Plant Extracts - analysis; Plant Extracts - metabolism; Plant Leaves - metabolism; Plant Stems - metabolism; Scrophulariaceae; Staphylococcus epidermidis; Staphylococcus epidermidis - metabolism; Trees; Halleria lucida; Antioxidant activities; Medicinal evaluation; Antibacterial properties; Pharmacological activity; Plant leaf; Antioxidant; Stem; Dicotyledones; Angiospermae; Scrophulariaceae; Spermatophyta; Antibacterial agent; Methanol
• ISSN: 0960-8524; 1873-2976
• DOI: 10.1016/j.biortech.2007.08.066

The medicinal potentials of the methanol extracts of the leaves and stems of Halleria lucida (Scrophulariaceae) were evaluated by assessing their antibacterial and antioxidant properties in vitro using standard procedures. The antioxidant activities of methanol extract of the leaves as determined by the ABTS, DPPH, proanthocyanidins and total flavonoids were higher than that of the stem. On the other hand, the total phenols, the flavonoids and the FRAP contents of the stem were higher than that of the leaves. The extracts however showed poor activity against both Gram-positive and Gram-negative bacteria. The methanol extract of the stem showed activities against Bacillus cereus and Staphylococcus epidermidis at MIC of 1.0 mg/ml. The methanol extract of the leaves did not show activity against any of the organisms used in this study. This study has to some extent validated the medicinal potential of the leaves and stems of H. lucida.