Nanotechnologic biosensor ellipsometry and biomarker pattern analysis in the evaluation of atherosclerotic risk profile

• Published in: Biosensors & bioelectronics Vol. 24; no. 5; pp. 1512 - 1517
• Main Authors: Siegel, G., Rodríguez, M., Sauer, F., Abletshauser, C., de Mey, C., Schötz, K., Ringstad, L., Malmsten, M., Schäfer, P.
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Kidlington Elsevier B.V 2009; Elsevier
• Subjects: Atherosclerosis - diagnosis; Atherosclerosis - metabolism; Atherosclerotic risk profile; Biological and medical sciences; Biomarker pattern analysis; Biomarkers - analysis; Biosensing Techniques - instrumentation; Biosensing Techniques - methods; Biosensors; Biotechnology; Equipment Design; Equipment Failure Analysis; Fundamental and applied biological sciences. Psychology; Ginkgo biloba; Humans; Lipoproteins - analysis; Methods. Procedures. Technologies; Nanotechnologic biosensor ellipsometry; Nanotechnology - instrumentation; Pattern Recognition, Automated - methods; Refractometry - instrumentation; Reproducibility of Results; Risk Assessment - methods; Risk Factors; Sensitivity and Specificity; Statins; statins -3 fatty acids; Various methods and equipments; ω-3 fatty acids; Ginkgo biloba; Biomarker pattern analysis; ω-3 fatty acids; Nanotechnologic biosensor ellipsometry; Statins; Atherosclerotic risk profile; Biological marker; n-3 fatty acid; Ellipsometry; Biosensor; Gymnospermae; Ginkgoales; Spermatophyta; Pattern analysis
• ISSN: 0956-5663; 1873-4235; 1873-4235
• DOI: 10.1016/j.bios.2008.08.011

A proteoheparan sulfate coated, hydrophobic silica surface serves as lipoprotein receptor at which the Ca 2+-driven arteriosclerotic nanoplaque formation can be pursued by laser-based ellipsometry. Any lipoprotein from human blood can be very sensitively tested for its atherogenic properties. From the same blood sample, it is possible to determine the concentration and activity of a series of interacting biomarker molecules which, through a pattern analysis, allow to assess the state of health with respect to cardiovascular diseases. These two interlinked and complementary biosensors make a prospective cardio-cerebro-vascular risk stratification feasible, especially the sequelae of an underlying arteriosclerotic disease. Based on these diagnostic tools, an optimized therapy decision for the patient can be taken and the necessary preventive measures for the still healthy person.