Nonribosomal peptide synthetases and their biotechnological potential in Penicillium rubens

Nonribosomal peptide synthetases (NRPS) are large multimodular enzymes that synthesize a diverse variety of peptides. Many of these are currently used as pharmaceuticals, thanks to their activity as antimicrobials (penicillin, vancomycin, daptomycin, echinocandin), immunosuppressant (cyclosporin) an...

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Published inJournal of industrial microbiology & biotechnology Vol. 48; no. 7-8; p. 1
Main Authors Iacovelli, Riccardo, Bovenberg, Roel A L, Driessen, Arnold J M
Format Journal Article
LanguageEnglish
Published Germany Oxford University Press 24.08.2021
Subjects
Amino acids
Beta lactam antibiotics
Beta lactamases
Immunosuppressive agents
Ligases
Natural Products
Penicillium - metabolism
Peptide Biosynthesis, Nucleic Acid-Independent
Peptide Synthases - genetics
Peptide Synthases - metabolism
Peptides
Physiological aspects
Antibiotics
Natural products
Nonribosomal peptide synthetases
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Summary:Nonribosomal peptide synthetases (NRPS) are large multimodular enzymes that synthesize a diverse variety of peptides. Many of these are currently used as pharmaceuticals, thanks to their activity as antimicrobials (penicillin, vancomycin, daptomycin, echinocandin), immunosuppressant (cyclosporin) and anticancer compounds (bleomycin). Because of their biotechnological potential, NRPSs have been extensively studied in the past decades. In this review, we provide an overview of the main structural and functional features of these enzymes, and we consider the challenges and prospects of engineering NRPSs for the synthesis of novel compounds. Furthermore, we discuss secondary metabolism and NRP synthesis in the filamentous fungus Penicillium rubens and examine its potential for the production of novel and modified β-lactam antibiotics.
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Present address: Department of Chemical and Pharmaceutical Biology, Groningen Research Institute of Pharmacy, University of Groningen, 9713 AV Groningen, The Netherlands.
ISSN:1367-5435
1476-5535
DOI:10.1093/jimb/kuab045