Activation of μ-opioid receptor and Toll-like receptor 4 by plasma from morphine-treated mice

Highlights • Both μ-opioid receptor and TLR4 can be activated by opioids or their metabolites. • Cell based assays can be used to quantify receptor agonism in biological samples. • Morphine administration results in circulating MOR and TLR4 agonism. • IP injections of morphine to mice every 12 h lea...

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Published inBrain, behavior, and immunity Vol. 61; pp. 244 - 258
Main Authors Xie, Nan, Gomes, Fabio P, Deora, Vandana, Gregory, Kye, Vithanage, Tharindu, Nassar, Zeyad D, Cabot, Peter, Sturgess, David, Shaw, Paul N, Parat, Marie-Odile
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Inc 01.03.2017
Subjects
Allergy and Immunology
Animals
Female
HEK293 Cells
Humans
Mice
Morphine
Morphine - pharmacology
Morphine Derivatives - pharmacology
Plasma - drug effects
Psychiatry
Receptors, Opioid, mu - metabolism
Signal Transduction - drug effects
TLR-4
TNFα
Toll-Like Receptor 4 - metabolism
μ-Opioid receptor
TLR-4
TNFα
μ-opioid receptor
morphine
μ-Opioid receptor
Morphine
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Summary:Highlights • Both μ-opioid receptor and TLR4 can be activated by opioids or their metabolites. • Cell based assays can be used to quantify receptor agonism in biological samples. • Morphine administration results in circulating MOR and TLR4 agonism. • IP injections of morphine to mice every 12 h lead to intermittent MOR activation. • This mode of morphine administration results in TLR4-independent NF-κB activation.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2016.12.002