Activation of μ-opioid receptor and Toll-like receptor 4 by plasma from morphine-treated mice
Highlights • Both μ-opioid receptor and TLR4 can be activated by opioids or their metabolites. • Cell based assays can be used to quantify receptor agonism in biological samples. • Morphine administration results in circulating MOR and TLR4 agonism. • IP injections of morphine to mice every 12 h lea...
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Published in | Brain, behavior, and immunity Vol. 61; pp. 244 - 258 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Netherlands
Elsevier Inc
01.03.2017
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Subjects | |
Online Access | Get full text |
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Summary: | Highlights • Both μ-opioid receptor and TLR4 can be activated by opioids or their metabolites. • Cell based assays can be used to quantify receptor agonism in biological samples. • Morphine administration results in circulating MOR and TLR4 agonism. • IP injections of morphine to mice every 12 h lead to intermittent MOR activation. • This mode of morphine administration results in TLR4-independent NF-κB activation. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0889-1591 1090-2139 |
DOI: | 10.1016/j.bbi.2016.12.002 |