How bacteria block their own biofilms

Bacterial biofilms are surface-associated multicellular communities that are highly resistant to removal. Scheffler et al. discovered that Pseudomonas aeruginosa secretes a small molecule that inhibits other P. aeruginosa cells from adsorbing to surfaces by interfering with type IV pili dynamics. Th...

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Bibliographic Details
Published inThe Journal of biological chemistry Vol. 296; p. 100392
Main Authors Delerue, Thomas, Ramamurthi, Kumaran S.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.01.2021
American Society for Biochemistry and Molecular Biology
Subjects
cystic fibrosis
E. coli
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natural products
secondary metabolite
Staphylococcus aureus
natural products
cystic fibrosis
E. coli
Staphylococcus aureus
secondary metabolite
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Summary:Bacterial biofilms are surface-associated multicellular communities that are highly resistant to removal. Scheffler et al. discovered that Pseudomonas aeruginosa secretes a small molecule that inhibits other P. aeruginosa cells from adsorbing to surfaces by interfering with type IV pili dynamics. The inhibition of cell adsorption could present a method to prevent biofilm formation on sensitive surfaces in hospitals and industry.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0021-9258
1083-351X
DOI:10.1016/j.jbc.2021.100392