Experimental challenges in ion channel research: uncovering basic principles of permeation and gating in potassium channels

• Published in: Advances in physics: X Vol. 7; no. 1
• Main Authors: Carvalho-de-Souza, Joao Luis, Saponaro, Andrea, Bassetto, C. A. Z., Rauh, Oliver, Schroeder, Indra, Franciolini, Fabio, Catacuzzeno, Luigi, Bezanilla, Francisco, Thiel, Gerhard, Moroni, Anna
• Format: Journal Article
• Language: English
• Published: Abingdon Taylor & Francis 01.01.2022; Taylor & Francis Ltd; Taylor & Francis Group
• Subjects: Binding sites; channel; Crystallography; gating; intramolecular communication; Ion channels; Ion transport; k+ channel; Ligands; Membranes; Penetration; Potassium; Proteins; selectivity filter; Sensors; Switches; voltage sensor

Biological ion channels precisely control the flow of ions across membranes in response to a range of physical and chemical stimuli. With their ability of transporting ions in a highly selective manner and of integrating regulatory cues, they are a source of inspiration for the construction of solid...