Experimental challenges in ion channel research: uncovering basic principles of permeation and gating in potassium channels

Biological ion channels precisely control the flow of ions across membranes in response to a range of physical and chemical stimuli. With their ability of transporting ions in a highly selective manner and of integrating regulatory cues, they are a source of inspiration for the construction of solid...

Full description

Saved in:
Bibliographic Details
Published inAdvances in physics: X Vol. 7; no. 1
Main Authors Carvalho-de-Souza, Joao Luis, Saponaro, Andrea, Bassetto, C. A. Z., Rauh, Oliver, Schroeder, Indra, Franciolini, Fabio, Catacuzzeno, Luigi, Bezanilla, Francisco, Thiel, Gerhard, Moroni, Anna
Format Journal Article
LanguageEnglish
Published Abingdon Taylor & Francis 01.01.2022
Taylor & Francis Ltd
Taylor & Francis Group
Subjects
Binding sites
channel
Crystallography
gating
intramolecular communication
Ion channels
Ion transport
k+ channel
Ligands
Membranes
Penetration
Potassium
Proteins
selectivity filter
Sensors
Switches
voltage sensor
Online AccessGet full text

Cover

More Information
Summary:Biological ion channels precisely control the flow of ions across membranes in response to a range of physical and chemical stimuli. With their ability of transporting ions in a highly selective manner and of integrating regulatory cues, they are a source of inspiration for the construction of solid-state nanopores as sensors or switches for practical applications. Here, we summarize recent advancements in understanding the mechanisms of ion permeation and gating in channel proteins with a focus on the elementary steps of ion transport through the pore and on non-canonical modes of intramolecular communication between peripheral sensory domains and the central channel pore.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ISSN:2374-6149
2374-6149
DOI:10.1080/23746149.2021.1978317