Heroin Abuse and/or HIV Infection Dysregulate Plasma Exosomal miRNAs
Exosomes play an important role in cell-to-cell communication as they can transfer functional molecules such as microRNAs (miRNAs) from one cell to another, exerting biological and immunological functions. Here, we investigated the impact of HIV infection and/or heroin use on the expression of the m...
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Published in | Journal of neuroimmune pharmacology Vol. 15; no. 3; pp. 400 - 408 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
New York
Springer US
01.09.2020
Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Summary: | Exosomes play an important role in cell-to-cell communication as they can transfer functional molecules such as microRNAs (miRNAs) from one cell to another, exerting biological and immunological functions. Here, we investigated the impact of HIV infection and/or heroin use on the expression of the miRNAs in plasma exosomes. We found that HIV infection or heroin use upregulated the majority (98%) of a panel of plasma exosomal miRNAs associated with immune regulation and inflammation. We also observed the enhanced effect of HIV infection and heroin use on some of these upregulated miRNAs. Our further investigation showed that the levels of four of neuro-inflammation-related miRNAs (146a, 126, 21, and let-7a) were higher in HIV-infected heroin users as compared with the control subjects. These findings indicate that the dysregulations of the plasma exosomal miRNAs support further studies to determine the role of the miRNAs in HIV and/or heroin use-mediated immune modulation and neuro-inflammation.
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 LS present address: Clinical Laboratory of the People’s Hospital of Henan Province, Zhengzhou 450003; China YZ present address: Eternity Bioscience Inc., 6 Cedarbrook Drive, Cranbury, NJ 08512; USA XW and LS contribute equally to this paper |
ISSN: | 1557-1890 1557-1904 |
DOI: | 10.1007/s11481-019-09892-9 |