Identifying targets to prevent aminoglycoside ototoxicity
Aminoglycosides are potent antibiotics that are commonly prescribed worldwide. Their use carries significant risks of ototoxicity by directly causing inner ear hair cell degeneration. Despite their ototoxic side effects, there are currently no approved antidotes. Here we review recent advances in ou...
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Published in | Molecular and cellular neuroscience Vol. 120; p. 103722 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
United States
Elsevier Inc
01.05.2022
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Subjects | |
Online Access | Get full text |
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Summary: | Aminoglycosides are potent antibiotics that are commonly prescribed worldwide. Their use carries significant risks of ototoxicity by directly causing inner ear hair cell degeneration. Despite their ototoxic side effects, there are currently no approved antidotes. Here we review recent advances in our understanding of aminoglycoside ototoxicity, mechanisms of drug transport, and promising sites for intervention to prevent ototoxicity.
•Aminoglycosides cause irreversible hearing loss by inducing cochlear hair cell death.•Diuretics and sepsis potentiate aminoglycoside uptake into the cochlea and ototoxicity.•Aminoglycoside enters hair cells via mechanotransducer channels.•Blockers of mechanotransducer channels or designer aminoglycosides prevent hair cell degeneration. |
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Bibliography: | equal contribution |
ISSN: | 1044-7431 1095-9327 |
DOI: | 10.1016/j.mcn.2022.103722 |