Functional divergence of duplicated c- myc genes in a tetraploid fish, the common carp ( Cyprinus carpio)

The proto-oncogene c- myc is thought to be one of the most important genes in controlling cell proliferation. In a tetraploid fish, two c- myc genes ( CAM1 and CAM2) were previously isolated from the common carp, Cyprinus carpio, and were shown to have different expression patterns in adult tissues....

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Bibliographic Details
Published inGene Vol. 363; pp. 61 - 66
Main Authors Futami, Kunihiko, Zhang, Huan, Okamoto, Nobuaki
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 19.12.2005
Subjects
Animals
Base Sequence
Carps - genetics
Cell Line
Cloning, Molecular
Cyprinus carpio
DNA Primers
Evolution
Gene Duplication
Gene Expression Regulation
Genes, myc
Max
Polyploidization
Polyploidy
Promoter Regions, Genetic
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger - genetics
Transcription, Genetic
Transfection
c-Myc
Max
RT-PCR
Polyploidization
GST
Evolution
cDNA
Gene duplication
c- myc
CAM2
CAM1
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Summary:The proto-oncogene c- myc is thought to be one of the most important genes in controlling cell proliferation. In a tetraploid fish, two c- myc genes ( CAM1 and CAM2) were previously isolated from the common carp, Cyprinus carpio, and were shown to have different expression patterns in adult tissues. Here we found that CAM1 and CAM2 proteins had distinct properties in terms of their transcription regulation system, formation of the transcription activator complex Myc/Max, and transcriptional activation of the target gene. These results showed that the two carp c-Myc proteins have overlapping but distinct functions, suggesting that CAM1 and CAM2 are evolving to acquire different functions after an earlier tetraploidization event.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0378-1119
1879-0038
DOI:10.1016/j.gene.2005.06.041