Mechanochemical synthesis of indolyl chalcones with antiproliferative activity
An efficient eco-friendly one-step mechanochemical synthesis of indole hybrid chalcones via the Claisen-Schmidt condensation of 1-methylindole-3-carboxaldehyde with various substituted acetophenones is described using liquid assisted grinding in a high-energy ball mill. The notable advantages of the...
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Published in | Green chemistry letters and reviews Vol. 15; no. 2; pp. 474 - 482 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Abingdon
Taylor & Francis
03.04.2022
Taylor & Francis Ltd Taylor & Francis Group |
Subjects | |
Online Access | Get full text |
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Summary: | An efficient eco-friendly one-step mechanochemical synthesis of indole hybrid chalcones via the Claisen-Schmidt condensation of 1-methylindole-3-carboxaldehyde with various substituted acetophenones is described using liquid assisted grinding in a high-energy ball mill. The notable advantages of the present method are small organic solvent required (100 μL ethanol) and mainly shorter reaction time (15-60 min) as compared to the conventional method. Antiproliferative activity of synthesized chalcones was studied on several human cancer cell lines (MCF-7, HeLa, A549, MDA-MB-231, HCT116) and non-cancer lines (Cos-7 or BJ-5ta). 3,4,5-Trimethoxyphenyl 3g, 2,5-dimethoxyphenyl 3h, and 2,4,5-trimethylphenyl 3j chalcones showed considerable cytotoxicity, particularly, chalcones 3h and 3j were identified as the most potent and selective anticancer agents with IC
50
values 7.9 and 6.6 μM, respectively, against the colon cancer HCT116 cell line. |
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ISSN: | 1751-8253 1751-7192 |
DOI: | 10.1080/17518253.2022.2089061 |