Clustering of HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) and infective dermatitis associated with HTLV-1 (IDH) in Salvador, Bahia, Brazil

• Published in: Journal of clinical virology Vol. 58; no. 2; pp. 482 - 485
• Main Authors: Silva, José Lucas Sena da, Primo, Janeusa Rita L, de Oliveira, Maria de Fátima S.P, Batista, Everton da Silva, Moreno-Carvalho, Otávio, Farré, Lourdes, Bittencourt, Achiléa L
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.10.2013
• Subjects: Adolescent; Adult; Allergy and Immunology; Brazil - epidemiology; Child; Child, Preschool; Cluster Analysis; Clustering of HTLV-1-associated diseases; Dermatitis - epidemiology; Dermatitis - virology; Female; HTLV-1 associated myelopathy/tropical spastic paraparesis; HTLV-1 infection; HTLV-1 vertical transmission; Human T-lymphotropic virus 1 - isolation & purification; Humans; Infant; Infectious Disease; Infective dermatitis associated with HTLV-1; Male; Middle Aged; Paraparesis, Tropical Spastic - epidemiology; Paraparesis, Tropical Spastic - virology; Brazil; Infective dermatitis associated with HTLV-1; Clustering of HTLV-1-associated diseases; HTLV-1 infection; HTLV-1 vertical transmission; HTLV-1 associated myelopathy/tropical spastic paraparesis
• ISSN: 1386-6532; 1873-5967
• DOI: 10.1016/j.jcv.2013.07.012

Abstract Fifteen families with clustering of infective dermatitis associated with HTLV-1 (IDH) and/or HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) were observed among 28 families of IDH index cases, 93% of them occurring in two generations. With the exception of two mothers of children with IDH, all the mothers with HAM/TSP had at least one child with HAM/TSP. This is the first report of such clustering involving many families.