Polarity during tissue repair, a multiscale problem

• Published in: Current opinion in cell biology Vol. 62; pp. 31 - 36
• Main Authors: Guzmán-Herrera, Alejandra, Mao, Yanlan
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.02.2020; Elsevier
• Subjects: Animals; Cell Polarity - physiology; Epithelium - physiopathology; Humans
• ISSN: 0955-0674; 1879-0410
• DOI: 10.1016/j.ceb.2019.07.015

[Display omitted] •Cell polarity is essential for repair across multiple scales.•Polarised cell behaviours, cytoskeletal and junctional components drive repair.•Polarity at the cellular level is crucial to restore and maintain tissue integrity.•Cell polarity affects tissue mechanics and, in turn, how a tissue responds to injury. Tissue repair is essential for all organisms, as it protects the integrity and function of tissues and prevents infections and diseases. It takes place at multiple scales, from macroscopic to microscopic levels. Most mechanisms driving tissue repair rely on the correct polarisation of collective cell behaviours, such as migration and proliferation, and polarisation of cytoskeletal and junctional components. Furthermore, re-establishment and maintenance of cell polarity are fundamental for a tissue to be fully repaired and for withstanding mechanical stress during homeostasis and repair. Recent evidence highlights an important role for the interplay between cell polarity and tissue mechanics that are critical in tissue repair.