Design of High-Sensitivity Surface Plasmon Resonance Sensor Based on Nanostructured Thin Films for Effective Detection of DNA Hybridization

• Published in: Plasmonics (Norwell, Mass.) Vol. 17; no. 4; pp. 1831 - 1841
• Main Authors: Ghayoor, Reza, Zangenehzadeh, Soraya, Keshavarz, Alireza
• Format: Journal Article
• Language: English
• Published: New York Springer US 2022; Springer Nature B.V
• Subjects: Biochemistry; Biological and Medical Physics; Biophysics; Biotechnology; Chemistry; Chemistry and Materials Science; Deoxyribonucleic acid; DNA; Figure of merit; Graphene; Infectious diseases; Low concentrations; Matrix methods; Nanostructure; Nanotechnology; Sensitivity; Surface plasmon resonance; Thickness; Thin films; Transfer matrices; Two dimensional materials; Viral diseases; Surface plasmon resonance; Coronavirus; Graphene; Quasi-photonic crystal; Biosensor based on the thin film
• ISSN: 1557-1955; 1557-1963
• DOI: 10.1007/s11468-022-01669-w

As developed countries’ ability to control infectious diseases increases, it has become clear that genetic diseases are a major cause of disability, death, and human tragedy. Coronavirus has recently spread throughout the world, and the capacity to detect low concentrations and virus changes can help to prevent the sickness from spreading further. In this paper, a surface plasmon resonance sensor based on nanostructured thin films and graphene as a 2D material has been designed with high sensitivity and accuracy to identify DNA-based infectious diseases such as SARS-CoV-2. The transfer matrix method assesses the effects of different structural factors, including nanolayer thickness on the sensor’s performance. The results demonstrated that the sensor with the Kretschmann configuration has ultra-high sensitivity (192.19 deg/RIU) and a high figure of merit (634.68 RIU −1 ).