SNP detection for massively parallel whole-genome resequencing

• Published in: Genome Research Vol. 19; no. 6; pp. 1124 - 1132
• Main Authors: Li, Ruiqiang, Li, Yingrui, Fang, Xiaodong, Yang, Huanming, Wang, Jian, Kristiansen, Karsten, Wang, Jun
• Format: Journal Article
• Language: English
• Published: United States Cold Spring Harbor Laboratory Press 01.06.2009
• Subjects: Algorithms; Asian Continental Ancestry Group - genetics; Chromosomes, Human, X - genetics; Computational Biology - methods; Genetics, Population - methods; Genome, Human - genetics; Genotype; Humans; Likelihood Functions; Models, Genetic; Models, Statistical; Polymorphism, Single Nucleotide; Probability; Reproducibility of Results; Resource; Sequence Analysis, DNA - instrumentation; Sequence Analysis, DNA - methods; Software

Next-generation massively parallel sequencing technologies provide ultrahigh throughput at two orders of magnitude lower unit cost than capillary Sanger sequencing technology. One of the key applications of next-generation sequencing is studying genetic variation between individuals using whole-geno...