Diagnosis of renal amyloidosis by liquid chromatography-tandem mass spectrometry: experience from a single-center cohort study in China

Laser microdissection coupled with liquid chromatography-tandem mass spectrometry (LMD/MS) can identify these proteins without the restriction of IF and IHC, although exquisite equipment and skilled specialists are required. [...]this study demonstrated that LMD/MS is superior to IHC in amyloid typi...

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Bibliographic Details
Published inChinese medical journal Vol. 135; no. 23; pp. 2888 - 2889
Main Authors Sun, Ying, Sun, Jian, Tao, Jianling, Sun, Wei, Li, Xuemei, Li, Mingxi
Format Journal Article
LanguageEnglish
Published China Lippincott Williams & Wilkins Ovid Technologies 05.12.2022
Lippincott Williams & Wilkins
Wolters Kluwer
Subjects
Amyloidosis
Amyloidosis - diagnosis
Apolipoproteins
Biopsy
China
Chromatography
Chromatography, Liquid
Cohort analysis
Cohort Studies
Consent
Correspondence
Humans
Mass spectrometry
Patients
Peptides
Proteins
Proteomics
Scientific imaging
Tandem Mass Spectrometry
China
United States > US
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Summary:Laser microdissection coupled with liquid chromatography-tandem mass spectrometry (LMD/MS) can identify these proteins without the restriction of IF and IHC, although exquisite equipment and skilled specialists are required. [...]this study demonstrated that LMD/MS is superior to IHC in amyloid typing, and is an important additional IHC method in the diagnosis of renal amyloidosis. Sun Y, Sun J, Tao J, Sun W, Li X, Li M. Diagnosis of renal amyloidosis by liquid chromatography-tandem mass spectrometry: experience from a single-center cohort study in China.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0366-6999
2542-5641
DOI:10.1097/CM9.0000000000002155