Emerging roles of epigenetic regulation in obesity and metabolic disease

Adipose tissue dysfunction is a hallmark of obesity and contributes to obesity-related sequelae such as metabolic complications and insulin resistance. Compelling evidence indicates that adipose-tissue-specific gene expression is influenced by gene interactions with proximal and distal cis-regulator...

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Bibliographic Details
Published inThe Journal of biological chemistry Vol. 297; no. 5; p. 101296
Main Authors Park, Yoon Jeong, Han, Sang Mun, Huh, Jin Young, Kim, Jae Bum
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.11.2021
American Society for Biochemistry and Molecular Biology
Subjects
adipose tissue
Adipose Tissue - metabolism
Adipose Tissue - pathology
CCCTC-binding factor
chromatin remodeling
Chromosomes, Human - genetics
Chromosomes, Human - metabolism
DNA Methylation
Epigenesis, Genetic
epigenetics
Humans
JBC Reviews
Metabolic Diseases - genetics
Metabolic Diseases - metabolism
Metabolic Diseases - pathology
obesity
Obesity - genetics
Obesity - metabolism
Obesity - pathology
three-dimensional chromosome conformation
CCCTC-binding factor
TET
FATP1
adipose tissue
chromatin remodeling
WAT
epigenetics
LAD
3C
NAD
DNMT
TF
TAD
LSD1
DNA methylation
pCHi-C
three-dimensional chromosome conformation
obesity
SAM
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Summary:Adipose tissue dysfunction is a hallmark of obesity and contributes to obesity-related sequelae such as metabolic complications and insulin resistance. Compelling evidence indicates that adipose-tissue-specific gene expression is influenced by gene interactions with proximal and distal cis-regulatory elements; the latter exert regulatory effects via three-dimensional (3D) chromosome conformation. Recent advances in determining the regulatory mechanisms reveal that compromised epigenomes are molecularly interlinked to altered cis-regulatory element activity and chromosome architecture in the adipose tissue. This review summarizes the roles of epigenomic components, particularly DNA methylation, in transcriptional rewiring in adipose tissue. In addition, we discuss the emerging roles of DNA methylation in the maintenance of 3D chromosome conformation and its pathophysiological significance concerning adipose tissue function.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0021-9258
1083-351X
DOI:10.1016/j.jbc.2021.101296