Immune thrombocytopenic purpura masking the fatal potential of calciphylaxis in a haemodialysis patient

Calciphylaxis on the background of immune thrombocytopenic purpura (ITP) has never been described. The pathogenesis of calciphylaxis is complex and not fully understood as yet. ITP has a complex pathogenesis that leads to bleeding or thrombotic events. Although ITP is treatable and reversible, calci...

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Published inCEN case reports Vol. 5; no. 1; pp. 70 - 73
Main Authors Lim, Thiam Seong Christopher, Thong, Kah Mean, Zakaria, Nor Fadhlina Binti, Thevandran, Kalaiselvam, Shah, Anim Md
Format Journal Article
LanguageEnglish
Published Tokyo Springer Japan 01.05.2016
Subjects
Case Report
Medicine
Medicine & Public Health
Nephrology
Urology
Calcification
Calciphylaxis
Immune thrombocytopenic purpura
End-stage renal failure
Necrosis
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Summary:Calciphylaxis on the background of immune thrombocytopenic purpura (ITP) has never been described. The pathogenesis of calciphylaxis is complex and not fully understood as yet. ITP has a complex pathogenesis that leads to bleeding or thrombotic events. Although ITP is treatable and reversible, calciphylaxis on the other hand, responds poorly to treatment and carries high mortality and morbidity. We present a case of a 56-year-old lady with end-stage renal disease with ITP, who complained of 1-month history of painful necrotic patches over the thighs. Due to delayed diagnosis, the patient deteriorated and passed away despite aggressive multidisciplinary approach. This case highlights the importance of early recognition of the increased thrombotic risk in an end-stage renal failure patient with poor phosphate control and ITP.
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ISSN:2192-4449
2192-4449
DOI:10.1007/s13730-015-0194-x