An investigation to the prolonged requirement (>7 days) of vasopressors in cervical spinal cord injury patients—a retrospective analysis

• Published in: Spinal cord series and cases Vol. 7; no. 1; p. 96
• Main Authors: Mishra, Rajeeb Kumar, Goyal, Keshav, Bindra, Ashish, Singh, Gyaninder Pal, Kumar, Niraj, Sokhal, Navdeep, Soni, Kapil Dev, Kedia, Shweta, Barman, Sagar Dev
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 02.11.2021; Nature Publishing Group
• Subjects: 59; 59/57; 692/1807/2781; 692/499; 692/700; 692/700/228/491; Anatomy; Biomedical and Life Sciences; Biomedicine; Dopamine; Human Physiology; Intensive care; Neurochemistry; Neuropsychology; Neurosciences; Spinal cord injuries
• ISSN: 2058-6124; 2058-6124
• DOI: 10.1038/s41394-021-00459-6

Study design Retrospective chart review. Objectives The primary aim was to identify the number of patients requiring vasopressors beyond the first week of cervical spinal cord injury (SCI). Secondary objectives were to note the type, duration and doses of vasopressors and any association between prolonged vasopressors use and outcome. Setting Neurosurgical intensive care of a tertiary trauma care centre. Methods After Ethical approval we retrospectively collected the data of patients of isolated cervical SCI admitted to neurosurgical intensive care from January to December 2017. Vasopressor requirement for sepsis or cardiac arrest was excluded. Results Out of 80 patients analysed, 54 (67.5%) received vasopressors. The prolonged requirement of vasopressors was observed in 77.7%. Our preferred agent was dopamine (64.8%). We found out that longer requirement (in days) of high dose of dopamine was associated with higher survival ( p  = 0.03). Conclusion Our results describe a significant portion of cervical SCI patients need ongoing vasopressor to maintain a mean arterial pressure >65 mm of Hg beyond first week. We observed patients who required longer duration of high dose dopamine had a higher chance of survival suggesting some unknown mechanism of high dose of dopamine. This is first such observation, further studies are needed to substantiate.