Facile design and development of nano-clustery graphene-based macromolecular protein hydrogel loaded with ciprofloxacin to antibacterial improvement for the treatment of burn wound injury

• Published in: Polymer bulletin (Berlin, Germany) Vol. 79; no. 9; pp. 7953 - 7968
• Main Authors: Zhu, Lipeng, Chen, Linlu
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.09.2022; Springer Nature B.V
• Subjects: Antibiotics; Bacteria; Bacterial infections; Biocompatibility; Biofilms; Cell growth; Characterization and Evaluation of Materials; Chemistry; Chemistry and Materials Science; Complex Fluids and Microfluidics; Composite materials; Cytotoxicity; Experiments; Fibroblasts; Graphene; Hydrogels; Infections; Organic Chemistry; Original Paper; Physical Chemistry; Physical properties; Polymer Sciences; Proteins; Silk; Silk fibroin; Skin; Soft and Granular Matter; Wound healing; China; Antibacterial activity; Silk fibroin; Graphene nano; Hydrogel; Ciprofloxacin; Burn wound
• ISSN: 0170-0839; 1436-2449
• DOI: 10.1007/s00289-021-03875-8

Nowadays, awareness about the burn wound is often considered difficult due to bacterial and other organism infections. The facile and eco-friendly preparations of antibiotic-loaded hydrogel-based bio-composites have great attention in the field of wound dressing for burn wound therapy and nursing care. In the present investigation, we have developed ciprofloxacin (CF)-encapsulated graphene-silk fibroin macromolecular hydrogel dressings material with unique chemical and physical properties to achieve the desirable antibacterial efficacy and healing activity. The antibacterial activity of prepared hydrogel was evaluated against bacterial pathogens treated with different concentrations of CF, which have been provided improved antibacterial activity on burn wound infection. In vitro , cytocompatibility evaluations were performed to imply the suitability of hydrogel on fibroblast cells, which has been dramatically related to in vivo wound healing. Furthermore, an in vivo wound healing analysis was carried out using a rat to observe the capability of the CF-incorporated GH/SF hydrogel matrix. Thus, this investigation widely demonstrates the healing ability of prepared hydrogel matrix and could be a significant landmark in the research on burn wound healing applications. Graphic abstract