Serum Ischemia-Modified Albumin Levels, Myeloperoxidase Activity and Peripheral Blood Mononuclear cells in Autism Spectrum Disorder (ASD)

• Published in: Journal of autism and developmental disorders Vol. 51; no. 7; pp. 2511 - 2517
• Main Authors: Ceylan, Mehmet Fatih, Tural Hesapcioglu, Selma, Yavas, Cansu Pınar, Senat, Almila, Erel, Ozcan
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.07.2021; Springer; Springer Nature B.V
• Subjects: Activity Units; Adolescents; Albumin; Anatomy; Autism; Autism Spectrum Disorders; Behavioral Science and Psychology; Biochemistry; Blood; Child and School Psychology; College Faculty; Control Groups; Correlation; Cytology; Development and progression; Diagnosis; Environmental aspects; Environmental factors; Environmental Influences; Genetic Disorders; Genetics; Health aspects; Hospitals; Identification; Imitation; Immune system; Interpersonal Relationship; Ischemia; Leukocytes (mononuclear); Leukocytes (neutrophilic); Lymphocytes; Measurement; Measurement Techniques; Metabolism; Monocytes; Motor Vehicles; Neurochemistry; Neurosciences; Nonverbal Communication; Original Paper; Oxidative stress; Patients; Pediatrics; Peripheral blood mononuclear cells; Peroxidase; Pervasive Developmental Disorders; Phenotypes; Psychological Patterns; Psychology; Public Health; Rating Scales; Research subjects; Risk factors; Serum; Verbal Communication; Turkey; ASD; Monocytes; Lymphocytes; Neutrophils; Ischemia-modified albumin; Myeloperoxidase; IMA; Autism spectrum disorder
• ISSN: 0162-3257; 1573-3432; 1573-3432
• DOI: 10.1007/s10803-020-04740-9

Genetic, neurobiological, neurochemical, environmental factors and their interactions contribute to autism phenotypes. Blood from 48 (age range: 4–17) autism spectrum disorder diagnosed patients (ASD) and 38 age- and gender-matched healthy control subjects was analyzed for numbers of neutrophils, lymphocytes, monocytes, albumin, serum Ischemia-Modified Albumin (IMA) levels and myeloperoxidase activity. The serum IMA levels, myeloperoxidase activity and peripheral blood mononuclear cells count were significantly higher in ASD cases than in the control subjects. There were no significant differences in albumin levels between the patient and control groups. These results suggest that the immune system, oxidative stress and myeloperoxidase activity may be activated in ASD. There is a clinical benefit from the early detection of ASD using myeloperoxidase activity, IMA levels and monocyte counts.