The effect of acutely administered phenytoin on vecuronium-induced neuromuscular blockade

Phenytoin was administered intravenously in a dose of 10 mg kg to a group of patients in whom steady state neuromuscular blockade had been established with an infusion of vecuronium. A control group of patients were given 0.9% saline instead of phenytoin. Administration of phenytoin produced signifi...

Full description

Saved in:
Bibliographic Details
Published inAnaesthesia Vol. 44; no. 5; p. 379
Main Authors Gray, H S, Slater, R M, Pollard, B J
Format Journal Article
LanguageEnglish
Published England 01.05.1989
Subjects
Adult
Humans
Infusions, Intravenous
Middle Aged
Neuromuscular Junction - drug effects
Phenytoin - administration & dosage
Time Factors
Vecuronium Bromide - administration & dosage
Online AccessGet more information

Cover

More Information
Summary:Phenytoin was administered intravenously in a dose of 10 mg kg to a group of patients in whom steady state neuromuscular blockade had been established with an infusion of vecuronium. A control group of patients were given 0.9% saline instead of phenytoin. Administration of phenytoin produced significant augmentation of neuromuscular blockade (p less than 0.001). The possible mechanism of this effect is discussed.
ISSN:0003-2409
DOI:10.1111/j.1365-2044.1989.tb11331.x