EMPEDOPEPTIN (BMY-28117), A NEW DEPSIPEPTIDE ANTIBIOTIC II. STRUCTURE DETERMINATION

Structure of a new antibiotic, empedopeptin, has been determined. It is a cyclic depsipeptide composed of two mol of D-serine and one mol each of β-hydroxytetradecanoic acid, L-arginine, D- and L-proline, L-3-hydroxyproline and D- and L-β-hydroxyaspartic acid. The sequence of these moieties was esta...

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Published inJournal of antibiotics Vol. 37; no. 9; pp. 958 - 964
Main Authors SUGAWARA, KOKO, NUMATA, KEI-ICHI, KONISHI, MASATAKA, KAWAGUCHI, HIROSHI
Format Journal Article
LanguageEnglish
Published Tokyo JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 1984
Japan Antibiotics Research Association
Subjects
Amino Acid Sequence
Anti-Bacterial Agents - analysis
Biological and medical sciences
Chemical Phenomena
Chemistry
Empedobacter halobacterium
empedopeptin
General pharmacology
Hydrolysis
Medical sciences
Oligopeptides - analysis
Pharmacology. Drug treatments
Physicochemical properties. Structure-activity relationships
Molecular structure
Depsipeptide
Antibiotic
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Summary:Structure of a new antibiotic, empedopeptin, has been determined. It is a cyclic depsipeptide composed of two mol of D-serine and one mol each of β-hydroxytetradecanoic acid, L-arginine, D- and L-proline, L-3-hydroxyproline and D- and L-β-hydroxyaspartic acid. The sequence of these moieties was established by partial hydrolysis and mass spectral analysis of the antibiotic.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.37.958