LANOMYCIN AND GLUCOLANOMYCIN, ANTIFUNGAL AGENTS PRODUCED BY Pycnidiophora dispersa I. DISCOVERY, ISOLATION AND BIOLOGICAL ACTIVITY

• Published in: Journal of antibiotics Vol. 45; no. 3; pp. 306 - 312
• Main Authors: O'SULLIVAN, JOSEPH, PHILLIPSON, DOUGLAS W., KIRSCH, DONALD R., FISHER, SUSAN M., LAI, MARGARET H., TREJO, WILLIAM H.
• Format: Journal Article
• Language: English
• Published: Tokyo JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 1992; Japan Antibiotics Research Association
• Subjects: Aminoglycosides; Animals; Anti-Bacterial Agents - isolation & purification; Anti-Bacterial Agents - pharmacology; Antibiotics (antibacterial agents, antifungal agents); Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents; Antifungal Agents - isolation & purification; Antifungal Agents - pharmacology; Applied microbiology; Ascomycota - metabolism; Bacteria - drug effects; Biological and medical sciences; Candida; Candida - drug effects; Ergosterol - biosynthesis; Female; Fermentation; Fundamental and applied biological sciences. Psychology; Mice; Microbiology; Pyrans - isolation & purification; Pyrans - pharmacology; Molecular structure; Biological activity; Fungi; Antifungal agent; Sensitivity resistance; Microbial origin; Gram positive bacteria; Candida; Isolation; Fungi Imperfecti; Aspergillus fumigatus; Thallophyta; Gram negative bacteria
• ISSN: 0021-8820; 1881-1469
• DOI: 10.7164/antibiotics.45.306

The antifungal agents lanomycin and glucolanomycin were isolated from Pycnidiophora dispersa. The compounds were active against species of Candida and dermatophytes but were inactive against Aspergillus fumigatus and Gram-positive and Gram-negative bacteria. The compounds inhibited the cytochrome P-450 enzyme lanosterol 14α-demethylase, and are believed, therefore, to have a mode of action similar to the azole and bis-triazole class of antifungal agents.