NaOH-Catalyzed Imine Synthesis: Aerobic Oxidative Coupling of Alcohols and Amines

• Published in: European journal of organic chemistry Vol. 2012; no. 24; pp. 4457 - 4460
• Main Authors: Donthiri, Ramachandra Reddy, Patil, Rajendra D., Adimurthy, Subbarayappa
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 01.08.2012; WILEY‐VCH Verlag; Wiley; Wiley-VCH; Wiley Subscription Services, Inc
• Subjects: Alcohols; Amines; Catalysis; Catalytic reactions; Chemistry; Chemistry, Organic; Exact sciences and technology; General and physical chemistry; Heterogeneous catalysis; Imines; Oxidative coupling; Physical Sciences; Science & Technology; Theory of reactions, general kinetics. Catalysis. Nomenclature, chemical documentation, computer chemistry; Heterogeneous catalysis; Amines; Imines; ONE-POT SYNTHESIS; N-ALKYLATION; RUTHENIUM; Oxidative coupling; SECONDARY-AMINES; EFFICIENT; Alcohols; HYDRIDE; AMIDES; Catalytic reaction; Alcohol; Transition metal; Air; Aerobe; Imine; Oxidant; Sodium hydroxide; Cosolvent; Amine; Chemical synthesis
• ISSN: 1434-193X; 1099-0690
• DOI: 10.1002/ejoc.201200716

The convenient transition‐metal‐free synthesis of imines through oxidative coupling of alcohols and amines is reported. The reaction is catalyzed by NaOH (10 mol‐%) and is performed with air as an oxidant in the absence of any co‐solvent. The convenient transition‐metal‐free synthesis of imines through oxidative coupling of alcohols and amines is reported. The reaction is catalyzed by NaOH (10 mol‐%) and is performed with air as an oxidant in the absence of any co‐solvent.