Synthesis of 5-Alkyl-4-oxazoleacetic Acid Derivatives with Hypolipidemic Activities

A series of 2-aryl and 2-alkyl derivatives of 5-alkyl-4-oxazoleacetic acids was synthesized and tested for hypolipidemic activity. Among them, 5-isopropyl-2-(4-fluorophenyl)-4-oxazoleacetates exhibited potent activities, being more active than clofibrate [ethyl 2-(4-chlorophenoxy) isobutvrate].

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Bibliographic Details
Published inChemical & pharmaceutical bulletin Vol. 36; no. 11; pp. 4435 - 4440
Main Authors SEKI, MASAHIKO, MORIYA, TAMON, MATSUMOTO, KAZUO, TAKASHIMA, KOHKI, MORI, TETSUJI, ODAWARA, AKIO, TAKEYAMA, SHIGEYUKI
Format Journal Article
LanguageEnglish
Published Tokyo The Pharmaceutical Society of Japan 01.11.1988
Maruzen
Japan Science and Technology Agency
Subjects
5-alkyl-4-oxazoleacetic acid
Acetates - chemical synthesis
Acetates - pharmacology
Animals
aspartic acid azlactone
Chemical Phenomena
Chemistry
Dakin-West reaction
Exact sciences and technology
Heterocyclic compounds
Heterocyclic compounds with n hetero atom and also o and/or s, se, te hetero atoms
hypocholesterolemic activity
hypolidemic agent
Hypolipidemic Agents - chemical synthesis
hypotriglyceridemic activity
In Vitro Techniques
Male
Organic chemistry
Oxazoles - chemical synthesis
Oxazoles - pharmacology
platelet aggregation inhibition
Preparations and properties
Rats
Rats, Inbred Strains
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Summary:A series of 2-aryl and 2-alkyl derivatives of 5-alkyl-4-oxazoleacetic acids was synthesized and tested for hypolipidemic activity. Among them, 5-isopropyl-2-(4-fluorophenyl)-4-oxazoleacetates exhibited potent activities, being more active than clofibrate [ethyl 2-(4-chlorophenoxy) isobutvrate].
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.36.4435