Does new photosensitizer improve photodynamic therapy in advanced esophageal carcinoma?

• Published in: Lasers in surgery and medicine Vol. 29; no. 4; pp. 323 - 327
• Main Authors: Maier, Alfred, Tomaselli, Florian, Matzi, Veronika, Rehak, Peter, Pinter, Hans, Smolle-Jüttner, Freyja M.
• Format: Journal Article
• Language: English
• Published: New York John Wiley & Sons, Inc 01.01.2001; Wiley-Liss
• Subjects: Adenocarcinoma - drug therapy; Adenocarcinoma - mortality; Adenocarcinoma - pathology; Aged; Aged, 80 and over; Aminolevulinic Acid - adverse effects; Aminolevulinic Acid - therapeutic use; Biological and medical sciences; Carcinoma, Squamous Cell - drug therapy; Carcinoma, Squamous Cell - mortality; Carcinoma, Squamous Cell - pathology; Deglutition Disorders - drug therapy; Deglutition Disorders - pathology; Dermatitis, Phototoxic - etiology; Diseases of the digestive system; esophageal cancer; Esophageal Neoplasms - drug therapy; Esophageal Neoplasms - mortality; Esophageal Neoplasms - pathology; Female; Hematoporphyrins - adverse effects; Hematoporphyrins - therapeutic use; Humans; Karnofsky Performance Status; Male; Medical sciences; Middle Aged; Photochemotherapy - adverse effects; photodynamic therapy; Photosensitizing Agents - adverse effects; Photosensitizing Agents - therapeutic use; Pilot Projects; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Survival Rate; Treatment Outcome; Human; Acyltransferases; Carcinoma; Photodynamic therapy; Enzyme; Transferases; Esophageal disease; Malignant tumor; 5-Aminolevulinate synthase; Esophagus; Association; Performance requirement; Secondary effect; Phototoxicity; Digestive diseases; Advanced stage; Photosensitizer

Background and Objective Polyhematoporphyrin (Photosan®) as sensitizers for photodynamic therapy (PDT) in advanced esophageal cancer carry the risk of prolonged photosensitivity of the skin. New sensitizers such as 5‐aminolaevulinic acid (ALA) with low rates of skin phototoxicity appear to be promis...