Does new photosensitizer improve photodynamic therapy in advanced esophageal carcinoma?

• Published in: Lasers in surgery and medicine Vol. 29; no. 4; pp. 323 - 327
• Main Authors: Maier, Alfred, Tomaselli, Florian, Matzi, Veronika, Rehak, Peter, Pinter, Hans, Smolle-Jüttner, Freyja M.
• Format: Journal Article
• Language: English
• Published: New York John Wiley & Sons, Inc 01.01.2001; Wiley-Liss
• Subjects: Adenocarcinoma - drug therapy; Adenocarcinoma - mortality; Adenocarcinoma - pathology; Aged; Aged, 80 and over; Aminolevulinic Acid - adverse effects; Aminolevulinic Acid - therapeutic use; Biological and medical sciences; Carcinoma, Squamous Cell - drug therapy; Carcinoma, Squamous Cell - mortality; Carcinoma, Squamous Cell - pathology; Deglutition Disorders - drug therapy; Deglutition Disorders - pathology; Dermatitis, Phototoxic - etiology; Diseases of the digestive system; esophageal cancer; Esophageal Neoplasms - drug therapy; Esophageal Neoplasms - mortality; Esophageal Neoplasms - pathology; Female; Hematoporphyrins - adverse effects; Hematoporphyrins - therapeutic use; Humans; Karnofsky Performance Status; Male; Medical sciences; Middle Aged; Photochemotherapy - adverse effects; photodynamic therapy; Photosensitizing Agents - adverse effects; Photosensitizing Agents - therapeutic use; Pilot Projects; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Survival Rate; Treatment Outcome; Human; Acyltransferases; Carcinoma; Photodynamic therapy; Enzyme; Transferases; Esophageal disease; Malignant tumor; 5-Aminolevulinate synthase; Esophagus; Association; Performance requirement; Secondary effect; Phototoxicity; Digestive diseases; Advanced stage; Photosensitizer
• DOI: 10.1002/lsm.1124
• ISSN: 0196-8092

Background and Objective Polyhematoporphyrin (Photosan®) as sensitizers for photodynamic therapy (PDT) in advanced esophageal cancer carry the risk of prolonged photosensitivity of the skin. New sensitizers such as 5‐aminolaevulinic acid (ALA) with low rates of skin phototoxicity appear to be promising alternatives. The aim of this study was to evaluate the efficacy of ALA compared to Photosan® for PDT in advanced esophageal carcinoma regarding phototoxicity of the skin, reduction of dysphagia, tumor stenosis, and tumor length and Karnovsky performance status. Study Design/Materials and Methods After diagnostic work‐up, photosensitization was done in 22 patients with ALA (60 mg/kg body weight, oral, 6–8 hours prior to PDT) and in 27 patients with Photosan® (2 mg/kg body weight, i.v., 48 hours before PDT). The light dose was calculated as 300 J/cm fibre tip. Light at 630 nm was applied using a pumped dye laser. In both groups, additional hyperbaric oxygenation was applied at a level of 2 absolute atmospheric pressure. Results Improvement regarding dysphagia, stenosis diameter, and tumor length could be obtained in both treatment arms with a significant difference in favour of the Photosan®‐group, P = 0.02; P = 0.0000; and P = 0.000014, respectively. The Karnovsky performance status also improved in both groups and showed no significant difference (P = 0.12). The median survival time for the ALA‐group was 8.0 months, compared with 9.0 months for the Photosan® group. No sunburn or other major treatment related complication occurred in both treatment arms. Thirty‐day mortality was 0%. Conclusion Despite the limitations of a non‐randomized study, photosensitzation with Photosan® seems to be more effective in PDT of advanced esophageal carcinoma compared to ALA. Lasers Surg. Med. 29:323–327, 2001. © 2001 Wiley‐Liss, Inc.