Molecular alterations in gastric cancer: the role of Helicobacter pylori

Helicobacter pylori has been classified as a human carcinogen contributing to the pathogenesis of gastric cancer. Extensive sero-epidemiological studies and recently animal experiments have established a close link between H. pylori infection and the development of gastric cancer. However, the molec...

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Bibliographic Details
Published inEuropean journal of gastroenterology & hepatology Vol. 12; no. 7; p. 795
Main Authors Ebert, M P, Yu, J, Sung, J J, Malfertheiner, P
Format Journal Article
LanguageEnglish
Published England 01.07.2000
Subjects
Animals
Cell Transformation, Neoplastic
Female
Gastric Mucosa - pathology
Helicobacter Infections - complications
Helicobacter Infections - microbiology
Helicobacter pylori - isolation & purification
Humans
Male
Molecular Biology
Risk Assessment
Sensitivity and Specificity
Stomach Neoplasms - genetics
Stomach Neoplasms - pathology
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Summary:Helicobacter pylori has been classified as a human carcinogen contributing to the pathogenesis of gastric cancer. Extensive sero-epidemiological studies and recently animal experiments have established a close link between H. pylori infection and the development of gastric cancer. However, the molecular changes induced by H. pylori directly or the concomitant chronic inflammation of the gastric mucosa, and the impact of these changes on the subsequent development of gastric cancer, remain largely unknown. This review will highlight the present knowledge on the molecular pathogenesis of gastric cancer with an emphasis on molecular and genetic alterations which develop due to chronic infection of the gastric mucosa by H. pylori.
ISSN:0954-691X
DOI:10.1097/00042737-200012070-00013