Otolaryngologic manifestations of antineutrophil cytoplasmic antibody-associated vasculitis

• Published in: Otolaryngology-head and neck surgery Vol. 146; no. 1; p. 119
• Main Authors: Nakamaru, Yuji, Takagi, Dai, Oridate, Nobuhiko, Homma, Akihiro, Fukuda, Satoshi
• Format: Journal Article
• Language: English
• Published: England 01.01.2012
• Subjects: Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - complications; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - immunology; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - metabolism; Antibodies, Antineutrophil Cytoplasmic - immunology; Antibodies, Antineutrophil Cytoplasmic - metabolism; Chronic Disease; Disease Progression; Follow-Up Studies; Hearing Loss, Sensorineural - diagnosis; Hearing Loss, Sensorineural - etiology; Hearing Loss, Sensorineural - immunology; Humans; Myeloblastin - immunology; Myeloblastin - metabolism; Otitis Media - etiology; Otitis Media - immunology; Otitis Media - metabolism; Peroxidase - immunology; Peroxidase - metabolism; Prognosis; Retrospective Studies
• ISSN: 1097-6817
• DOI: 10.1177/0194599811424044

Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is characterized by systemic necrotizing vasculitis, and patients fall into 2 groups: those with proteinase 3-ANCA and those with myeloperoxidase-ANCA. As infections are a trigger of ANCA-associated vasculitis, this disease tends to localize in areas around the upper airway. In this study, the authors compared ear and nasal symptoms between patients with proteinase 3-ANCA and those with myeloperoxidase-ANCA. We undertook a retrospective case series study of 34 patients diagnosed with ANCA-associated vasculitis. The otologic symptoms were divided into 3 types: chronic otitis media, secretory otitis media, and sensorineural hearing loss. Chronic otitis media was more common in patients with proteinase 3-ANCA (P = .001), whereas secretory otitis media was more frequently found in patients with myeloperoxidase-ANCA (P = .007). Crust formation (P = .001), saddle nose (P = .024), and sinusitis (P = .001) were more common in patients with proteinase 3-ANCA than in those with myeloperoxidase-ANCA. Marked differences were observed in the disease spectrum between the 2 ANCA groups.