Capacity of Candida species to produce acetaldehyde at various concentrations of alcohol

• Published in: Journal of oral and maxillofacial pathology : JOMFP Vol. 26; no. 2; pp. 161 - 165
• Main Authors: Reddy, Mamatha, Kakodkar, Pradnya, Nayanar, Gayatri
• Format: Journal Article
• Language: English
• Published: Chennai Wolters Kluwer India Pvt. Ltd 01.04.2022; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Wolters Kluwer - Medknow
• Subjects: Acetaldehyde; Alcohol; Alcohol dehydrogenase; Bank clearinghouses; Candida; Candida krusei; Clinical isolates; Drinking of alcoholic beverages; Gas chromatography; Headspace; Oral cancer; Original; Smoking; Species; Spectrophotometry; alcohol; Candida albicans; Candida species; oral cancer; Acetaldehyde
• ISSN: 0973-029X; 1998-393X
• DOI: 10.4103/jomfp.jomfp_494_20

Background: Along with tobacco use, alcohol consumption is one of the crucial factors for oral cancer. Acetaldehyde (ACH), a byproduct of alcohol, is reported as carcinogenic. One of the producers of ACH from alcohol is Candida species. The aim of the study was to quantify the ACH produced by Candida species at various concentrations of alcohol. Materials and Methods: Clinical isolates of Candida, namely Candida albicans, Candida krusei and Candida tropicalis and C. albicans ATCC 18,804, were subjected to various concentrations of alcohol. Alcohol dehydrogenase and ACH were estimated using spectrophotometry and headspace gas chromatography, respectively. Results: Out of all three clinical isolates, C. tropicalis produced more ACH (412.1 μM) at 10 mM alcohol concentration by 105 colony-forming unit/ml followed by C. albicans (233 μM) and C. krusei (53.7 μM). C. albicans of clinical isolate and ATCC species (222 μM) did not show much difference. Conclusion: The study results conclude that Candida species are capable of producing carcinogenic levels of ACH on exposure to various concentrations of alcohol.