The apoptotic and autophagic properties of two natural occurring prodrugs, hyperoside and hypoxoside, against pancreatic cancer cell lines

• Published in: Biomedicine & pharmacotherapy Vol. 83; pp. 617 - 626
• Main Authors: Boukes, Gerhardt J, van de Venter, Maryna
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01.10.2016
• Subjects: Acridine Orange - metabolism; Alkynes - chemistry; Alkynes - pharmacology; Alkynes - therapeutic use; Animals; Apoptosis; Apoptosis - drug effects; Autophagosomes - drug effects; Autophagosomes - metabolism; Autophagy; Autophagy - drug effects; Biomarkers, Tumor - metabolism; Caspase 3 - metabolism; Cell Cycle Checkpoints - drug effects; Cell Line, Tumor; Cell Nucleus - drug effects; Cell Nucleus - metabolism; DNA - metabolism; Enzyme Activation - drug effects; Glucosides - chemistry; Glucosides - pharmacology; Glucosides - therapeutic use; Humans; Hyperoside; Hypoxoside; INS-1; Internal Medicine; Medical Education; MIA PaCa-2; Microtubule-Associated Proteins - metabolism; Pancreatic Neoplasms - drug therapy; Pancreatic Neoplasms - pathology; Prodrugs - chemistry; Prodrugs - pharmacology; Prodrugs - therapeutic use; Quercetin - analogs & derivatives; Quercetin - chemistry; Quercetin - pharmacology; Quercetin - therapeutic use; Rats; Staining and Labeling; Harpagoside (PubChem CID: 5281542); ethylene diaminetetraacetic acid; COX-2; DMSO; LC3B; cyclooxygenase-2; 3-(4,5-dimethyl-2-thiazolul)-2,5-diphenyl-2H-tetrazolium bromide; MIA PaCa-2; Polydatin (PubChem CID: 5281718); Hyperoside; PARP; MTT; AP-1; Autophagy; NF-κB; Hypoxoside; FITC; mammalian target of rapamycin; CREB; dimethyl sulfoxide; Hypoxoside (PubChem CID: 6438448; PI3K; mTOR; light chain 3B; INS-1; fluorescein isothiocyanate; cAMP response element binding protein; poly (ADP-ribose) polymerase; extracellular signal-regulated kinases; STAT3; Hyperoside (PubChem CID: 5281643); nuclear factor-kappa B; activating protein-1; signal transducer and activator of transcription 3; EDTA; Oleuropein (PubChem CID: 5281544); AO; acridine orange; phosphatidyl-3-kinase; DPBS; Dulbecco’s phosphate buffered saline; ERK; Apoptosis
• ISSN: 0753-3322; 1950-6007
• DOI: 10.1016/j.biopha.2016.07.029

Graphical abstract