Pre-clinical anti-inflammatory aspects of a cuisine and medicinal millennial herb: Malva sylvestris L

• Published in: Food and chemical toxicology Vol. 58; pp. 324 - 331
• Main Authors: Prudente, Arthur S., Loddi, Alliete M.V., Duarte, Márcia R., Santos, Adair R.S., Pochapski, Marcia T., Pizzolatti, Moacir G., Hayashi, Sirlei S., Campos, Francinete R., Pontarolo, Roberto, Santos, Fabio A., Cabrini, Daniela A., Otuki, Michel F.
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.08.2013; Elsevier
• Subjects: Animals; anti-inflammatory activity; Anti-Inflammatory Agents - chemistry; Anti-Inflammatory Agents - pharmacology; Biological and medical sciences; cell movement; Chromatography, Liquid; cuisine; Ear oedema; ears; edema; Female; General pharmacology; inflammation; interleukin-1beta; Interleukin-1beta - metabolism; Interleukin-1β; leaves; Malva - chemistry; Malva sylvestris; malvidin; Medical sciences; Mice; Mouse; Peroxidase - metabolism; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Plants, Medicinal; quercetin; salads; scopoletin; Skin; skin diseases; soups; Spectrometry, Mass, Electrospray Ionization; Topic anti-inflammatory; topical application; Toxicology; Topic anti-inflammatory; Ear oedema; Skin; Malva sylvestris; Mouse; Interleukin-1β; Edema; Rodentia; Antiinflammatory agent; Medicinal plant; Interieukin-1β; Vertebrata; Mammalia; Animal; Ear; Plant origin
• ISSN: 0278-6915; 1873-6351
• DOI: 10.1016/j.fct.2013.04.042

•M. sylvestris extract and compounds inhibits skin edema induced by TPA.•M. sylvestris reduces leukocytes migration in skin inflammation.•M. sylvestris inhibits skin IL-1β amount. Malva sylvestris has been used since ancient times for its emollient, laxative and anti-inflammatory properties, being extensively used as salads, soups and teas. The preset study evaluated the topical anti-inflammatory action of M. sylvestris hydroalcoholic extract (HE) and its compounds in mice ear inflammation caused by 12-O-tetradecanoylphorbol-acetate in mice. The LC–MS analysis of the HE confirmed the presence of scopoletin, quercetin and malvidin 3-glucoside compounds in the HE of M. sylvestris. Topical application of the HE reduced ear oedema, polymorphonuclear cells influx (myeloperoxydase activity and histological analysis) and interleukin-1β levels in the tissue. The topical application of the compound present in the HE, malvidin 3-glucoside was also able to inhibit ear oedema and leukocytes migration. The other tested compounds, scopoletin, quercetin and malvidin 3,5-glucoside were able to prevent the formation of oedema and cell infiltration, but with less effectiveness when compared to HE and malvidin 3-glucoside. Therefore, these results consistently support the notion that M. sylvestris leaves possesses topical anti-inflammatory activity, the compound malvidin 3-glucoside seems to be major responsible for this effect, with the participation of other anti-inflammatory compounds in the extract. Thus, as recommended by population, M. sylvestris can be used as a future treatment to skin disorders.