An unusual case of seizures in a 5-year-old Syrian female with abdominal tuberculosis: an isoniazid therapeutic dose side effect

ABSTRACT Isoniazid (INH) is highly bactericidal against replicating tubercule bacilli and is involved in all antituberculous chemotherapeutic regimens. Several neurological adverse effects, following both therapeutic and overdose use of INH, have been reported in adults in the literature. Here, we p...

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Published inOxford Medical Case Reports Vol. 2021; no. 1; p. omaa126
Main Authors Mohammad, Lava, Doya, Leen, Omran, Razan, Ibrahim, Alexander, Alshehabi, Zuheir, Ibrahim, Ali
Format Journal Article
LanguageEnglish
Published England Oxford University Press 01.01.2021
Subjects
Case Report
gastroenterology and hepatology
infectious diseases and tropical medicine
pediatrics
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Summary:ABSTRACT Isoniazid (INH) is highly bactericidal against replicating tubercule bacilli and is involved in all antituberculous chemotherapeutic regimens. Several neurological adverse effects, following both therapeutic and overdose use of INH, have been reported in adults in the literature. Here, we present a case of a 5-year-old girl with intestinal Tuberculosis, who developed hemiclonic seizure as a side effect of INH therapeutic dose after 2 weeks of tuberculosis therapy.
ISSN:2053-8855
2053-8855
DOI:10.1093/omcr/omaa126