Identification of antitumor activity of pyrazole oxime ethers

A series of pyrazole oxime ether derivatives were prepared and examined as cytotoxic agents. In particular, 5-phenoxypyrazole was comparable to doxorubicin, while exhibiting very potent cytotoxicity against XF 498 and HCT15. A series of pyrazole oxime ether derivatives were prepared and examined as...

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Bibliographic Details
Published inBioorganic & medicinal chemistry letters Vol. 15; no. 13; pp. 3307 - 3312
Main Authors Park, Hyun-Ja, Lee, Kyung, Park, Su-Jin, Ahn, Bangle, Lee, Jong-Cheol, Cho, HeeYeong, Lee, Kee-In
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 01.07.2005
Elsevier
Subjects
Antineoplastic agents
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - pharmacology
Biological and medical sciences
Cell Line, Tumor
Cell Proliferation - drug effects
Chloroformylation
Cytotoxicity
Drug Screening Assays, Antitumor
Ethers
General aspects
Humans
Inhibitory Concentration 50
Medical sciences
Oximes
Pharmacology. Drug treatments
Pyrazole oxime ether
Pyrazoles - chemical synthesis
Pyrazoles - pharmacology
Pyrazolone
Cytotoxicity
Pyrazolone
Chloroformylation
Pyrazole oxime ether
Antineoplastic agent
Human
Solid tumor
Central nervous system
Oxime
Malignant tumor
Doxorubicin
In vitro
Biological activity
Benzoic acid derivatives
Cell line
Pyrazole derivatives
Colon
Chemical synthesis
Tumor cell
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Summary:A series of pyrazole oxime ether derivatives were prepared and examined as cytotoxic agents. In particular, 5-phenoxypyrazole was comparable to doxorubicin, while exhibiting very potent cytotoxicity against XF 498 and HCT15. A series of pyrazole oxime ether derivatives were prepared and examined as cytotoxic agents. In particular, 5-phenoxypyrazole was comparable to doxorubicin, while exhibiting very potent cytotoxicity against XF 498 and HCT15.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2005.03.082