An In Vitro Assessment of Aerosol Delivery Through Patient Breathing Circuits Used with Medical Air or a Helium―Oxygen Mixture

• Published in: Journal of aerosol medicine Vol. 24; no. 5; pp. 225 - 234
• Main Authors: MARTIN, Andrew R, ANG, Angela, KATZ, Ira M, HAUSSERMANN, Sabine, CAILLIBOTTE, Georges, TEXEREAU, Joëlle
• Format: Journal Article
• Language: English
• Published: New Rochelle, NY Mary Ann Liebert 01.10.2011; Mary Ann Liebert, Inc
• Subjects: Aerosol deposition; Aerosol therapy; Aerosols - administration & dosage; Biological and medical sciences; Diffraction; General pharmacology; Health aspects; Health technology assessment; Helium - administration & dosage; Humans; Humidity; Lasers; Medical sciences; Nebulizers and Vaporizers; Oxygen - administration & dosage; Particle Size; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Respiration; France; United States; Delivery system; Human; Evaluation; Oxygen; Pharmaceutical technology; aerosol deposition; noninvasive ventilation; Droplet; In vitro; Mixture; droplet size distribution; helium-oxygen; Distribution; Non invasive method; Metered dose inhaler; laser diffraction; Pharmacokinetics; Nebulizer; Deposition
• ISSN: 1941-2711; 1941-2703; 1941-2703
• DOI: 10.1089/jamp.2010.0871

The bench experiments presented herein were conducted in order to investigate the influence of carrier gas, either medical air or a helium-oxygen mixture (78% He, 22% O2), on the droplet size distribution and aerosol mass delivered from a vibrating mesh nebulizer through a patient breathing circuit. Droplet size distributions at the exit of the nebulizer T-piece and at the patient end of the breathing circuit were determined by laser diffraction. Additional experiments were performed to determine the effects on measured size distributions of gas humidity and of the droplet residence time during transport from the nebulizer to the laser diffraction measurement volume. Aerosol deposition in the nebulizer, breathing circuit, and on expiratory and patient filters was determined by photometry following nebulization of sodium fluoride solutions into the breathing circuit during simulated patient breathing. With no humidification of the carrier gas, droplet volume median diameter (VMD) at the exit of the nebulizer T-piece was 5.5±0.1 μm for medical air, and 4.3±0.1 μm for helium-oxygen. Varying the aerosol residence time between the nebulizer and the measurement volume did not affect the measured size distributions; however, humidification of the carrier gases reduced differences in VMD at the nebulizer exit between medical air and helium-oxygen. At the patient end of the breathing circuit, droplet VMDs were 1.8±0.1 μm for medical air and 2.2±0.1 μm for helium-oxygen. The percentages of sodium fluoride recovered from the nebulizer, breathing circuit, patient filter, and expiratory filter were, respectively, 29.9±8.3, 40.4±5.6, 8.3±1.5, and 21.5±2.1% for air, and 32.6±2.2, 36.3±0.7, 12.0±1.4, and 19.1±1.1% for helium-oxygen. Ventilation with helium-oxygen in place of air-oxygen mixtures can influence both the droplet size distribution and mass of nebulized aerosol delivered through patient breathing circuits. Assessment of these effects on aerosol delivery is important when incorporating helium-oxygen into patient ventilation strategies.