Analytical methodologies for the determination of cisplatin

• Published in: Journal of pharmaceutical and biomedical analysis Vol. 47; no. 3; pp. 451 - 459
• Main Authors: Bosch, M. Espinosa, Sánchez, A.J. Ruiz, Rojas, F. Sánchez, Ojeda, C. Bosch
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 15.07.2008; Elsevier Science
• Subjects: Analysis; Analytical methodologies; Analytical, structural and metabolic biochemistry; Biological and medical sciences; Chromatography, High Pressure Liquid; Cisplatin; Cisplatin - analysis; Electrochemistry; Electrophoresis, Capillary; Fundamental and applied biological sciences. Psychology; General pharmacology; Mass Spectrometry; Medical sciences; Pharmaceutical analysis; Pharmacology. Drug treatments; Review; Spectrophotometry, Ultraviolet; Pharmaceutical analysis; Review; Analytical methodologies; Cisplatin; Antineoplastic agent; Drug; Divalent metal Complexes; Chemical analysis; Transition metal Complexes; Determination; Alkylating agent; Platinum II Complexes; Quantitative analysis
• ISSN: 0731-7085; 1873-264X
• DOI: 10.1016/j.jpba.2008.01.047

cis-Diamminedichloroplatinum(II) (cisplatin) is a important chemotherapeutic drug for cancer treatment since 1978. Unfortunately, because of the severe side-effects like nephrotoxicity, ototoxicity, etc., they are administered in small doses at low concentration establishing the maximum limit dosage to 100 mg/m 2 (21 days). A variety of analytical methods have been proposed for the determination of cisplatin in biological fluids and tissues that permit the accurate determination at or below the part per billion level in the native sample. The purpose of the current review is to provide a systematic survey of the latest analytical techniques for the determination of cisplatin in biological samples.