Analytical methodologies for the determination of cisplatin

cis-Diamminedichloroplatinum(II) (cisplatin) is a important chemotherapeutic drug for cancer treatment since 1978. Unfortunately, because of the severe side-effects like nephrotoxicity, ototoxicity, etc., they are administered in small doses at low concentration establishing the maximum limit dosage...

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Bibliographic Details
Published inJournal of pharmaceutical and biomedical analysis Vol. 47; no. 3; pp. 451 - 459
Main Authors Bosch, M. Espinosa, Sánchez, A.J. Ruiz, Rojas, F. Sánchez, Ojeda, C. Bosch
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier B.V 15.07.2008
Elsevier Science
Subjects
Analysis
Analytical methodologies
Analytical, structural and metabolic biochemistry
Biological and medical sciences
Chromatography, High Pressure Liquid
Cisplatin
Cisplatin - analysis
Electrochemistry
Electrophoresis, Capillary
Fundamental and applied biological sciences. Psychology
General pharmacology
Mass Spectrometry
Medical sciences
Pharmaceutical analysis
Pharmacology. Drug treatments
Review
Spectrophotometry, Ultraviolet
Pharmaceutical analysis
Review
Analytical methodologies
Cisplatin
Antineoplastic agent
Drug
Divalent metal Complexes
Chemical analysis
Transition metal Complexes
Determination
Alkylating agent
Platinum II Complexes
Quantitative analysis
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Summary:cis-Diamminedichloroplatinum(II) (cisplatin) is a important chemotherapeutic drug for cancer treatment since 1978. Unfortunately, because of the severe side-effects like nephrotoxicity, ototoxicity, etc., they are administered in small doses at low concentration establishing the maximum limit dosage to 100 mg/m 2 (21 days). A variety of analytical methods have been proposed for the determination of cisplatin in biological fluids and tissues that permit the accurate determination at or below the part per billion level in the native sample. The purpose of the current review is to provide a systematic survey of the latest analytical techniques for the determination of cisplatin in biological samples.
ISSN:0731-7085
1873-264X
DOI:10.1016/j.jpba.2008.01.047