Role of Dopaminergic Mechanisms in the Formation of Stress-Induced Ulcer Damages to the Duodenum and Stomach in Rats

Intraperitoneal injections of 2.5 mg/kg reserpine daily for 3 days combined with immobilization/pain stress evoked the development of ulcerous damages to the duodenum and stomach in rats. This is accompanied by increases in the content of malonic dialdehyde (MDA) and activity of superoxide dismutase...

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Published inNeurophysiology (New York) Vol. 44; no. 1; pp. 79 - 82
Main Authors Antonyan, I. S., Godlevskii, L. S.
Format Journal Article
LanguageEnglish
Published Boston Springer US 01.04.2012
Springer
Springer Nature B.V
Subjects
Ascorbic acid
Biomedical and Life Sciences
Biomedicine
Blood
Corticosteroids
Digestive system
Dopamine
Duodenum
Erythrocytes
Immobilization
Nervous system
Neurobiology
Neurosciences
Pain
Pentoxifylline
Reserpine
Rodents
Selegiline
Stomach
Stress
Superoxide
Superoxide dismutase
Ulcers
pentoxifylline
immobilization/pain stress
dopaminergic system
L-deprenyl
ulcers of the duodenum and stomach
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Summary:Intraperitoneal injections of 2.5 mg/kg reserpine daily for 3 days combined with immobilization/pain stress evoked the development of ulcerous damages to the duodenum and stomach in rats. This is accompanied by increases in the content of malonic dialdehyde (MDA) and activity of superoxide dismutase (SOD) in erythrocytes, level of vitamin C in the blood plasma, and activity of SOD in a homogenate of the duodenum tissue. Injections of 0.5 mg/kg L-deprenyl (i.p.) and 50 mg/kg pentoxifylline (i.p.) provided protection effects with respect to stress-induced ulcers; the influences of these agents were mutually potentiated.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0090-2977
1573-9007
DOI:10.1007/s11062-012-9271-3