Increased Soluble Tumor Necrosis Factor Receptor Levels in the Serum of Elderly People

• Published in: Gerontology (Basel) Vol. 46; no. 4; pp. 185 - 188
• Main Authors: Hasegawa, Yoshiya, Sawada, Makoto, Ozaki, Norio, Inagaki, Toshiaki, Suzumura, Akio
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland Karger 01.07.2000; S. Karger AG
• Subjects: Adult; Aged; Aged, 80 and over; Aging - blood; Alzheimer Disease - blood; Antigens, CD - blood; Biological and medical sciences; Clinical Section; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Female; Humans; Macrophage Colony-Stimulating Factor - blood; Male; Medical sciences; Middle Aged; Neurology; Receptors, Tumor Necrosis Factor - blood; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; Reference Values; Solubility; Soluble interleukin-6 receptor; Soluble tumor necrosis factor receptors; Proinflammatory cytokines; Soluble cytokine receptors; Elderly; Interleukin-1 receptor antagonist; Human; Nervous system diseases; Senescence; Pathophysiology; Alzheimer disease; Cytokine; Malignant tumor; Cerebral disorder; Infection; Granulocyte colony stimulating factor; Tumor necrosis factor; Central nervous system disease; Interleukin 1; Degenerative disease; Macrophage colony stimulating factor; Biological receptor

Background: Soluble (s) forms of tumor necrosis factor (TNF) receptors are the only natural molecules known to interfere with TNF activity by competing for TNF binding with receptors on target cells. In a variety of pathologic situations, the concentrations of sTNF receptors (R) increase. Objective:...