Increased Soluble Tumor Necrosis Factor Receptor Levels in the Serum of Elderly People

• Published in: Gerontology (Basel) Vol. 46; no. 4; pp. 185 - 188
• Main Authors: Hasegawa, Yoshiya, Sawada, Makoto, Ozaki, Norio, Inagaki, Toshiaki, Suzumura, Akio
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland Karger 01.07.2000; S. Karger AG
• Subjects: Adult; Aged; Aged, 80 and over; Aging - blood; Alzheimer Disease - blood; Antigens, CD - blood; Biological and medical sciences; Clinical Section; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Female; Humans; Macrophage Colony-Stimulating Factor - blood; Male; Medical sciences; Middle Aged; Neurology; Receptors, Tumor Necrosis Factor - blood; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; Reference Values; Solubility; Soluble interleukin-6 receptor; Soluble tumor necrosis factor receptors; Proinflammatory cytokines; Soluble cytokine receptors; Elderly; Interleukin-1 receptor antagonist; Human; Nervous system diseases; Senescence; Pathophysiology; Alzheimer disease; Cytokine; Malignant tumor; Cerebral disorder; Infection; Granulocyte colony stimulating factor; Tumor necrosis factor; Central nervous system disease; Interleukin 1; Degenerative disease; Macrophage colony stimulating factor; Biological receptor
• ISSN: 0304-324X; 1423-0003
• DOI: 10.1159/000022157

Background: Soluble (s) forms of tumor necrosis factor (TNF) receptors are the only natural molecules known to interfere with TNF activity by competing for TNF binding with receptors on target cells. In a variety of pathologic situations, the concentrations of sTNF receptors (R) increase. Objective: To discuss possible causes of increased risks for infectious disease and cancer seen in the elderly. Methods: The participants were healthy subjects (n = 48) of three age groups (young, middle-aged, and elderly). Patients with senile dementia of Alzheimer type (n = 25) were also studied. For detection of cytokines, interleukin (IL) 1α, IL-1β, IL-6, macrophage colony-stimulating factor (M-CSF), granulocyte colony-stimulating factor, and TNF-α were measured in serum by enzyme-linked immunosorbent assays, as were soluble (s) IL-1 receptor antagonist (IL-1ra), sIL-6R, p55sTNF-R, and p75sTNF-R. Results: IL-1α, IL-1β, IL-6, and TNF-α were not detected, and sIL-6R and IL-1ra concentrations were not significantly different between the three age groups. However, sTNF-R and M-CSF were increased in sera from the elderly, both healthy and demented. A significant correlation was seen between sTNF-R and M-CSF concentrations. Conclusions: Increased sTNF-R levels may oppose the physiologic and protective effects of TNF by interference with its receptor binding. This interaction may contribute to the susceptibility of the elderly to infectious and neoplastic diseases.