Comparative Characteristics of the Spleen White Pulp in Experimental Models of Sepsis Caused by Different Strains of Pseudomonas aeruginosa

We describe reactive changes in the spleen white pulp in male C57BL/6 mice with experimental sepsis induced by intraperitoneal administration of Pseudomonas aeruginosa 1840 ( Pa1840 ) with exotoxin U gene or Pseudomonas aeruginosa 1623 ( Pa1623 ) with exotoxin S gene. Histological analysis and morph...

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Published inBulletin of experimental biology and medicine Vol. 170; no. 1; pp. 46 - 48
Main Authors Cherkasova, M. N., Zhukhovitskii, V. G., Borovaya, T. G.
Format Journal Article
LanguageEnglish
Published New York Springer US 01.11.2020
Springer
Springer Nature B.V
Subjects
Apoptosis
Biomedical and Life Sciences
Biomedicine
Cell Biology
Comparative analysis
Exotoxins
Hyperplasia
Hypoplasia
Infection
Internal Medicine
Laboratory Medicine
Morphometry
Pathology
Pseudomonas aeruginosa
S gene
Sepsis
Spleen
White pulp
white pulp
Pseudomonas aeruginosa
spleen
sepsis
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Summary:We describe reactive changes in the spleen white pulp in male C57BL/6 mice with experimental sepsis induced by intraperitoneal administration of Pseudomonas aeruginosa 1840 ( Pa1840 ) with exotoxin U gene or Pseudomonas aeruginosa 1623 ( Pa1623 ) with exotoxin S gene. Histological analysis and morphometry revealed hypoplasia of the spleen white pulp in mice with sepsis induced by Pa1840 , while sepsis caused by Pa1623 was associated with its hyperplasia; with apoptosis of white pulp cells was observed in both cases. The results attest to ambiguous nature of the reactive changes in the white pulp of the spleen in experimental sepsis models initiated by Pa1840 and Pa1623 stains.
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ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-020-05001-6