Disseminated Mycobacterial Infection in a Hemophilia B Patient with Acquired Immunodeficiency Syndrome

• Published in: Japanese Journal of Medicine Vol. 29; no. 4; pp. 442 - 447
• Main Authors: WADA, Hideo, OHIWA, Michiaki, MORI, Yoshitaka, TANIGAWA, Motoaki, TAMAKI, Shigehisa, KOBAYASHI, Thoru, MINAMI, Nobuyuki, DEGUCHI, Katsumi, SHIRAKAWA, Shigeru, KUSANO, Itsuo, YATANI, Ryuichi
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Society of Internal Medicine 1990
• Subjects: Acquired Immunodeficiency Syndrome - complications; Acquired Immunodeficiency Syndrome - diagnosis; Adult; AIDS encephalitis; AIDS/HIV; Blood Cell Count; Blotting, Western; Brain - diagnostic imaging; Brain - pathology; Hemophilia B - complications; HIV; Humans; Male; Mycobacterium Infections - diagnosis; Mycobacterium Infections - pathology; Opportunistic infections; Radiography; Spleen - pathology
• ISSN: 0021-5120; 1881-123X
• DOI: 10.2169/internalmedicine1962.29.442

Disseminated mycobacterial infection was found at autopsy in a male patient with hemophilia B and acquired immunodeficiency syndrome (AIDS). In May 1986, 23 months before death, the patient had encephalitis for one month and in July he developed a fever, malaise and generalized lymphoadenopathy. Human immunosuppressive virus (HIV) was positive and the CD 4/8 ratio of lymphocyte surface markers was 0.1, but mycobacterium was not detected. In September 1986, he had severe dyspnea due to interstitial pneumonia and he was treated with high-dose methylprednisolone. He died after a 23-month course of fever, severe weight loss and terminal progressive deterioration, although he was treated with antibiotics, antifungal agents, γ-globulin, steroid and a Azidothymidine.