Inroads into the structure and function of intermediate filament networks

Although intermediate filaments are one of three major cytoskeletal systems of vertebrate cells, they remain the least understood with respect to their structure and function. This is due in part to the fact that they are encoded by a large gene family which is developmentally regulated in a cell an...

Full description

Saved in:
Bibliographic Details
Published inJournal of structural biology Vol. 177; no. 1; pp. 14 - 23
Main Authors Goldman, Robert D., Cleland, Megan M., Murthy, S.N. Prasanna, Mahammad, Saleemulla, Kuczmarski, Edward R.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.01.2012
Subjects
Animals
Cell motility
Cell Movement
Cytoskeleton - metabolism
Cytoskeleton - ultrastructure
Intermediate filaments
Intermediate Filaments - metabolism
Intermediate Filaments - ultrastructure
Keratin
Keratins - metabolism
Keratins - ultrastructure
Phosphorylation
Vimentin
Vimentin - metabolism
Vimentin - ultrastructure
Vimentin
Keratin
Cell motility
Phosphorylation
Intermediate filaments
Online AccessGet full text

Cover

More Information
Summary:Although intermediate filaments are one of three major cytoskeletal systems of vertebrate cells, they remain the least understood with respect to their structure and function. This is due in part to the fact that they are encoded by a large gene family which is developmentally regulated in a cell and tissue type specific fashion. This article is in honor of Ueli Aebi. It highlights the studies on IF that have been carried out by our laboratory for more than 40 years. Many of our advances in understanding IF are based on conversations with Ueli which have taken place during adventurous and sometimes dangerous hiking and biking trips throughout the world.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1047-8477
1095-8657
DOI:10.1016/j.jsb.2011.11.017