Combination of PDT photosensitizers with NO photodononors

Combination of photodynamic therapy (PDT) with other treatment modalities is emerging as one of the most suitable strategies to increase the effectiveness of therapeutic action on cancer and bacterial diseases and to minimize side effects. This approach aims at exploiting the additive/synergistic ef...

Full description

Saved in:
Bibliographic Details
Published inPhotochemical & photobiological sciences Vol. 17; no. 11; pp. 179 - 1727
Main Authors Fraix, Aurore, Sortino, Salvatore
Format Journal Article
LanguageEnglish
Published Cham Springer International Publishing 01.11.2018
Royal Society of Chemistry
Subjects
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - metabolism
Anti-Bacterial Agents - pharmacology
Antineoplastic Agents - chemistry
Antineoplastic Agents - metabolism
Antineoplastic Agents - pharmacology
Bacteria - drug effects
Bacterial diseases
Biochemistry
Biomaterials
Cancer
Chemistry
Humans
Neoplasms - drug therapy
Nitric oxide
Nitric Oxide - chemistry
Nitric Oxide - metabolism
Photochemical Processes
Photochemotherapy
Photodynamic therapy
Photosensitizing Agents - chemistry
Photosensitizing Agents - metabolism
Photosensitizing Agents - pharmacology
Physical Chemistry
Plant Sciences
Side effects
Synergistic effect
Online AccessGet full text

Cover

More Information
Summary:Combination of photodynamic therapy (PDT) with other treatment modalities is emerging as one of the most suitable strategies to increase the effectiveness of therapeutic action on cancer and bacterial diseases and to minimize side effects. This approach aims at exploiting the additive/synergistic effects arising from multiple therapeutic species acting on different mechanistic pathways. The coupling of PDT with photocontrolled release of nitric oxide (NO) through the appropriate assembly of PDT photosensitizers (PSs) and NO photodonors (NOPDs) may open up intriguing avenues towards new and still underexplored multimodal therapies not based on "conventional" drugs but entirely controlled by light stimuli. In this contribution, we present an overview of the most recent advances in this field, illustrating several strategies to assemble PSs and NOPDs allowing them to operate independently without reciprocal interferences and describing the potential applications with particular emphasis on their impact in anticancer and antibacterial research. The appropriate assembly of PDT photosensitizers and NO photodonors may open up intriguing avenues towards new and still underexplored multimodal therapies not based on "conventional" drugs but entirely controlled by light stimuli.
Bibliography:Salvatore Sortino received his Ph.D. in Chemical Sciences in 1994 from the University of Catania (Italy) and carried out postdoctoral research at the CNR of Bologna (Italy) until 1996. In the same year he joined the University of Catania where he is now Full Professor of Chemistry. He was a visiting scientist at the University of Ottawa (Canada) in 1998-1999 (Prof. J. C. Scaiano) and at the University of Miami (USA) in 2004 and 2011 (Prof. F. M. Raymo). He has authored about 200 publications and 2 patents in the field of photochemistry. His current scientific interests mainly focus on the development of light-activatable nanoconstructs for biomedical applications.
Aurore Fraix received her Ph.D. in Chemistry in 2010 from the University of Brest (France). In 2011 she joined Prof. Sortino's research group at the University of Catania as a Marie Curie postdoctoral research fellow and since 2017 she is assistant professor. Her current research interests are focused on the design, synthesis and characterization of molecular assemblies for multimodal therapy applications. She has co-authored about 40 publications and 1 patent in the field of controlled biomedical release.
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1474-905X
1474-9092
DOI:10.1039/c8pp00272j