Effect of Glycodelin on the Cytokine Profile of Rats during Allogeneic Bone Marrow Cell Transplantation

• Published in: Bulletin of experimental biology and medicine Vol. 173; no. 5; pp. 636 - 640
• Main Authors: Bochkova, M. S., Timganova, V. P., Shardina, K. Yu, Uzhviyuk, S. V., Loginova, N. P., Troinich, Ya. N., Zamorina, S. A.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.09.2022; Springer; Springer Nature B.V
• Subjects: B cells; Biological products; Biomedical and Life Sciences; Biomedicine; Bone marrow; Bone marrow transplantation; Cell Biology; Chemokines; Cytokines; Experiments; Graft rejection; Growth factors; IL-1β; Inflammation; Interleukin 12; Interleukin 18; Interleukin 7; Internal Medicine; Laboratory animals; Laboratory Medicine; Macrophage colony-stimulating factor; Medical research; Pathology; Physiology; Pregnancy; Rodents; Software; Transplantation; Transplants & implants; Wistar rats; cytokine profile; allogeneic transplant; glycodelin
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-022-05603-2

The protein glycodelin (PP14, PAEP) is associated with pregnancy and exhibits pronounced immunotropic properties. We studied the effect of glycodelin on the cytokine profile of blood serum during transplantation a suspension of allogeneic red bone marrow cells to Wistar rats. Recombinant glycodelin was administered to the animals 4 times (14 μg each time). Against the background of bone marrow cell transplantation, the levels of proinflammatory (IL-1α, IL-1β, and IL-18) and regulatory (IL-7, IL-12) cytokines and CSF (M-CSF) increased in blood serum, which indicates a systemic inflammatory response to the allograft. Glycodelin administration against the background of bone marrow cell allotransplantation led to a significant decrease in the proinflammatory cytokine IL-17A on day 21 of the experiment; the concentrations of the other cytokines remained unchanged. In general, glycodelin can suppress the level of IL-17A, a marker of graft rejection, which opens perspectives for its further investigation as a potential drug.