Neural dynamics in parkinsonian brain: the boundary between synchronized and nonsynchronized dynamics

Synchronous oscillatory dynamics is frequently observed in the human brain. We analyze the fine temporal structure of phase-locking in a realistic network model and match it with the experimental data from Parkinsonian patients. We show that the experimentally observed intermittent synchrony can be...

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Bibliographic Details
Published inPhysical review. E, Statistical, nonlinear, and soft matter physics Vol. 83; no. 4 Pt 1; p. 042901
Main Authors Park, Choongseok, Worth, Robert M, Rubchinsky, Leonid L
Format Journal Article
LanguageEnglish
Published United States 01.04.2011
Subjects
Action Potentials
Animals
Biological Clocks
Brain - physiopathology
Computer Simulation
Cortical Synchronization
Humans
Models, Neurological
Nerve Net - physiopathology
Neurons
Synaptic Transmission
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Summary:Synchronous oscillatory dynamics is frequently observed in the human brain. We analyze the fine temporal structure of phase-locking in a realistic network model and match it with the experimental data from Parkinsonian patients. We show that the experimentally observed intermittent synchrony can be generated just by moderately increased coupling strength in the basal ganglia circuits due to the lack of dopamine. Comparison of the experimental and modeling data suggest that brain activity in Parkinson's disease resides in the large boundary region between synchronized and nonsynchronized dynamics. Being on the edge of synchrony may allow for easy formation of transient neuronal assemblies.
ISSN:1550-2376
DOI:10.1103/PhysRevE.83.042901