Multiple sclerosis in Caucasians and Latino Americans

Epidemiological and genetic studies suggest that the prevalence, median age of onset, and specific phenotypes of multiple sclerosis (MS) are different in Caucasians and Latino Americans. Recent epidemiological studies indicate an increase in MS prevalence in Latin America (LA), where the south-north...

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Published inAutoimmunity (Chur, Switzerland) Vol. 44; no. 7; pp. 571 - 575
Main Authors Aguirre-Cruz, Lucinda, Flores-Rivera, José, De La Cruz-Aguilera, Dora Luz, Rangel-López, Edgar, Corona, Teresa
Format Journal Article
LanguageEnglish
Published England Informa Healthcare 01.11.2011
Taylor & Francis
Subjects
Amerindians
Demyelinating disease
European Continental Ancestry Group
Genetic Predisposition to Disease
Hispanic Americans
Humans
Latin America
Latin America - epidemiology
Mestizos
Mongoloid genes
Multiple Sclerosis - epidemiology
Multiple Sclerosis - ethnology
Prevalence
Latin America
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Summary:Epidemiological and genetic studies suggest that the prevalence, median age of onset, and specific phenotypes of multiple sclerosis (MS) are different in Caucasians and Latino Americans. Recent epidemiological studies indicate an increase in MS prevalence in Latin America (LA), where the south-north gradient of latitude described for Nordic countries does not exist. Analysis of MS epidemiological and specific aspects in LA suggests that susceptibility and clinical behavior of the disease are related to mixtures and admixtures of genes in the population. MS is not present in Amerindians with Mongoloid genes, such as occurs in other pure ethnic groups. Surely, future studies will be carried out to obtain more reliable information. In this review, we contrast and analyze the available data of MS in LA and endemic countries.
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ISSN:0891-6934
1607-842X
DOI:10.3109/08916934.2011.592887